- Potent Antioxidant*
- Supports Weight Loss*
- Supports Glucose Control*
- Promotes Liver Detoxification*
Lipoic Acid has become one of Bevko’s most popular products, not only for its antioxidant and detoxification properties, but also because it aids in weight loss and energy production. Read on for more information about lipoic acid’s powerful properties!
Suggested Use: As a dietary supplement, adults take one (1) or more tablets per day as directed by your healthcare provider. (Note: Urine odor is common when taking lipoic acid.)
Lipoic Acid: The Universal Antioxidant
Lipoic acid is a coenzyme that has many functions in the body. It aids cellular energy production by converting carbohydrates (sugar) to energy. Lipoic acid is also a powerful antioxidant. Called the universal antioxidant because it is both fat-soluble and water-soluble, lipoic acid can destroy more free radicals than most antioxidants.
Supports Glucose Control
In Germany, lipoic acid has been used to help diabetics with their blood sugar (as well as with complications of diabetes such as diabetic neuropathy).
*When taking lipoic acid, some diabetics may need to reduce their medication or insulin, and they should discuss this with their physician.
Promotes Liver Detoxification
Lipoic acid’s antioxidant qualities have been used by some practitioners to help with liver problems. In a medical article(1), Dr. Burton Berkson described the use of lipoic acid, along with silymarin and selenium, to treat three patients with extensive liver disease caused by hepatitis C. Using that combination, all three patients were able to avoid liver transplantation and to return to work feeling healthy!
Promotes Weight Loss
Your body's cells need lipoic acid to be able to metabolize sugars into energy. When you more efficiently turn sugars into energy, you have more energy, and that sugar doesn't have a chance to turn into fat! As people get older they often have difficulty with this process. As a result, they often have problems losing weight and may have a build-up of fat, especially around the waist. Some of our customers have reported a reduction in cellulite after several months of using lipoic acid.Some studies have shown that lipoic acid can help support weight loss by suppressing hypothalamic AMPK activity.
Assists Memory and Brain Function
In Europe, some researcher have found that lipoic acid can have a positive effect on long term memory in older mice. The authors of these studies believe that lipoic acid can compensate for age-related long-term memory loss. Some scientists believe that lipoic acid may be helpful in the treatment of Alzheimer's disease and other neurological problems.
Reduces Effects of Strokes and Heart Attacks
Strokes and heart attacks are caused by clogged blood vessels. Some scientists believe that antioxidants like lipoic acid can help protect blood vessels from the development of clogged arteries. Researchers estimate that the addition of antioxidants by supplementation could decrease the risk of heart attack by 20-30%!(2) Yet other studies show that lipoic acid may help preserve more brain tissue after a stroke.
(1)Berkson, BM. A conservative triple antioxidant approach to the treatment of hepatitis C. Combination of alpha lipoic acid (thioctic acid), silymarin, and selenium: three case histories. Medizinische Klinik, 94 Suppl 3:84-89, 1999 Oct. 15. (2) Hennekens, C., and Gaziano, M. 1993. Antioxidants and heart disease. Clinical Cardiology 16:10-15.
1)Janero DR. Ischemic heart disease and antioxidants: mechanistic aspects of oxidative injury and its prevention. [Review] [120 refs] [Journal Article. Review. Review, Tutorial] Critical Reviews in Food Science & Nutrition. 35(1-2):65-81, 1995 Jan.
2)Hoffman RM. Garewal HS. Antioxidants and the prevention of coronary heart disease.[comment]. [Review] [71 refs] [Journal Article. Review. Review, Tutorial] Archives of Internal Medicine. 155(3):241-6, 1995 Feb 13. We own from 1970-
3) Hennekens CH. Gaziano JM. Antioxidants and heart disease: epidemiology and clinical evidence. [Review] [36 refs] [Journal Article. Review. Review, Tutorial] Clinical Cardiology. 16(4 Suppl 1):I10-3; discussion I13-5, 1993 Apr.
4)Eichholzer M. Stahelin HB. Gey KF. Inverse correlation between essential antioxidants in plasma and subsequent risk to develop cancer, ischemic heart disease and stroke respectively: 12-year follow-up of the Prospective Basel Study. [Journal Article] EXS. 62:398-410, 1992.
5)Gey KF. Puska P. Plasma vitamins E and A inversely correlated to mortality from ischemic heart disease in cross-cultural epidemiology. [Journal Article] Annals of the New York Academy of Sciences. 570:268-82, 1989.
6) Scott BC. Aruoma OI. Evans PJ. O'Neill C. Van der Vliet A. Cross CE. Tritschler H. Halliwell B. Lipoic and dihydrolipoic acids as antioxidants. A critical evaluation. [Journal Article] Free Radical Research. 20(2):119-33, 1994 Feb.
7)Bustamante J. Lodge JK. Marcocci L. Tritschler HJ. Packer L. Rihn BH. Alpha-lipoic acid in liver metabolism and disease. [Review] [141 refs] [Journal Article. Review. Review, Tutorial] Free Radical Biology & Medicine. 24(6):1023-39, 1998 Apr.
8) Jacob S. Henriksen EJ. Schiemann AL. Simon I. Clancy DE. Tritschler HJ. Jung WI. Augustin HJ. Dietze GJ. Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid. [Clinical Trial. Controlled Clinical Trial. Journal Article] Arzneimittel-Forschung. 45(8):872-4, 1995 Aug.
9)Khamaisi M, Potashnik R, Tirosh A, Demshchak E, Rudich A, Tritschler H, et al. Lipoic acid reduces glycemia and increases muscle GLUT4 content in streptozotocin diabetic rats. Metabolism 1997;46:763-8. 10) Estrada DE. Ewart HS. Tsakiridis T. Volchuk A. Ramlal T. Tritschler H. Klip A. Stimulation of glucose uptake by the natural coenzyme alpha-lipoic acid/thioctic acid: participation of elements of the insulin signaling pathway. [Journal Article] Diabetes. 45(12):1798-804, 1996 Dec.
11) Packer L. Antioxidant properties of lipoic acid and its therapeutic effects in prevention of diabetes complications and cataracts. Ann NY Acad Sci 1994;738:257-64. 12) Nagamatsu M. Nickander KK. Schmelzer JD. Raya A. Wittrock DA. Tritschler H. Low PA. Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy. [Journal Article] Diabetes Care. 18(8):1160-7, 1995 Aug.
13) Ametov AS. Barinov A. Dyck PJ. Hermann R. Kozlova N. Litchy WJ. Low PA. Nehrdich D. Novosadova M. O'Brien PC. Reljanovic M. Samigullin R. Schuette K. Strokov I. Tritschler HJ. Wessel K. Yakhno N. Ziegler D. SYDNEY Trial Study Group. The sensory symptoms of diabetic polyneuropathy are improved with alpha-lipoic acid: the SYDNEY trial. [Clinical Trial. Journal Article. Randomized Controlled Trial] Diabetes Care. 26(3):770-6, 2003 Mar 14) Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant alpha-lipoic acid. Diabetologia 1995;38:1425-33. 15) Packer L. Antioxidant properties of lipoic acid and its therapeutic effects in prevention of diabetes complications and cataracts. Ann NY Acad Sci 1994;738:257-64. 16) Maitra I. Serbinova E. Tritschler HJ. Packer L. Stereospecific effects of R-lipoic acid on buthionine sulfoximine-induced cataract formation in newborn rats. [Journal Article] Biochemical & Biophysical Research Communications. 221(2):422-9, 1996 Apr 16.
17) Maitra I. Serbinova E. Trischler H. Packer L. Alpha-lipoic acid prevents buthionine sulfoximine-induced cataract formation in newborn rats. [Journal Article] Free Radical Biology & Medicine. 18 (4):823-9, 1995 Apr.
18) Baur A. Harrer T. Peukert M. Jahn G. Kalden JR. Fleckenstein B. Alpha-lipoic acid is an effective inhibitor of human immuno-deficiency virus (HIV-1) replication. [Journal Article] Klinische Wochenschrift. 69(15):722-4, 1991 Oct 2.
19) Kagan VE. Shvedova A. Serbinova E. Khan S. Swanson C. Powell R. Packer L. Dihydrolipoic acid--a universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals. [Journal Article] Biochemical Pharmacology. 44(8):1637-49, 1992 Oct 20 20) Koenig ML. Meyerhoff JL. In vitro neuroprotection against oxidative stress by pre-treatment with a combination of dihydrolipoic acid and phenyl-butyl nitrones. [Journal Article] Neurotoxicity Research. 5(4):265-72, 2003.
21) Hagen TM. Liu J. Lykkesfeldt J. Wehr CM. Ingersoll RT. Vinarsky V. Bartholomew JC. Ames BN. Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress.[erratum appears in Proc Natl Acad Sci U S A 2002 May 14;99(10):7184]. [Journal Article] Proceedings of the National Academy of Sciences of the United States of America. 99(4):1870-5, 2002 Feb 19. 22) Hagen TM. Ingersoll RT. Lykkesfeldt J. Liu J. Wehr CM. Vinarsky V. Bartholomew JC. Ames AB. (R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate. [Journal Article] FASEB Journal. 13(2):411-8, 1999 Feb. 23) Lykkesfeldt J. Hagen TM. Vinarsky V. Ames BN. Age-associated decline in ascorbic acid concentration, recycling, and biosynthesis in rat hepatocytes--reversal with (R)-alpha-lipoic acid supplementation. [Journal Article] FASEB Journal. 12(12):1183-9, 1998 Sep.
24) Liu J. Head E. Gharib AM. Yuan W. Ingersoll RT. Hagen TM. Cotman CW. Ames BN. Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid.[erratum appears in Proc Natl Acad Sci U S A 2002 May 14;99(10):7184-5]. [Journal Article] Proceedings of the National Academy of Sciences of the United States of America. 99(4):2356-61, 2002 Feb 19.
25) Hagen TM. Liu J. Lykkesfeldt J. Wehr CM. Ingersoll RT. Vinarsky V. Bartholomew JC. Ames BN. Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress.[erratum appears in Proc Natl Acad Sci U S A 2002 May 14;99(10):7184]. [Journal Article] Proceedings of the National Academy of Sciences of the United States of America. 99(4):1870-5, 2002 Feb 19.
26) Hagen TM. Ingersoll RT. Lykkesfeldt J. Liu J. Wehr CM. Vinarsky V. Bartholomew JC. Ames AB. (R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate. [Journal Article] FASEB Journal. 13(2):411-8, 1999 Feb.
27) Moini H. Tirosh O. Park YC. Cho KJ. Packer L. R-alpha-lipoic acid action on cell redox status, the insulin receptor, and glucose uptake in 3T3-L1 adipocytes. [Journal Article] Archives of Biochemistry & Biophysics. 397(2):384-91, 2002 Jan 15.