Other ingredients: sorbitol, natural cherry flavor, cherry juice concentrate, vegetable stearic acid, magnesium stearate, and croscarmellose.

This product is free of gluten, dairy, corn, peanut, soy, artificial colors and preservatives.  

Suggested Use: As a dietary supplement, take one (1) or more lozenges daily or as directed by your physician or healthcare provider. Dissolve one lozenge under the tongue or chew thoroughly and swallow.

Caution: If you are pregnant or nursing, consult with your physician or healthcare provider before using this product.

120 Cherry Lozenges

Product Description:

Vitamin B12 is different than other water-soluble nutrients because some B12 is usually stored in some organs, mainly the liver, the kidney, and other tissues. Consequently, the symptoms and signs of B12 deficiency may not appear until after 5-6 years of poor intake or reduced absorption. This essential vitamin helps maintain healthy brain, nerve, and red blood cells, and also assists in red blood cell formation.*

Active Folate (Methyltetrahydrofolic Acid), also known as vitamin B9, helps the body make new cells and plays a major role in preventing birth defects of the spine. Because Folic Acid supplementation can mask signs of B12 deficiency, it's very important to take active folate in combination with B12.*

Suggested Use: As a dietary supplement, take one (1) or more lozenges daily or as recommended by your physician or health care professional. Dissolve one lozenge under the tongue or chew thoroughly and swallow.

CAUTION: If pregnant or lactating, use under the direction of your physician or healthcare provider.

Importance of Vitamin B12

B12 helps:

• form red blood cells*
• the function of all of the body’s cells, most importantly the brain cells, nerve cells, and red blood cells.*
• rebuild important genetic materials called nucleic acids.*
• reduce certain forms of anemia*
• reduce homocysteine levels*

Homocysteine

Along with vitamin B6 and folic acid, B12 may help patients who do not get enough of these important nutrients to reduce their homocysteine blood levels. Homocysteine is an amino acid, and having too much of it is considered to be a risk factor for heart disease.*

High homocysteine levels in the blood can damage the lining of the arteries, and may make blood clot more easily than it should. This can increase the risk of blood vessel blockages, making the individual have a higher risk of heart attack or stroke.*

Signs of B12 Deficiency

A deficiency in B12 can cause a number of symptoms:

• impaired nerve function*
• numbness, tingling, burning sensations*
• impaired mental functioning (not unlike Alzheimer’s)*
• depression*
• anemia*
• fatigue*

Even though pernicious anemia is the classic symptom of B12 deficiency, the brain and nervous system are affected first!*

Active Folate

Active Folate, well known for its role in preventing birth defects, also provides other health benefits. One of the most important benefits is the reduction of homocysteine levels in the body. High levels of homocysteine have been implicated in conditions such as coronary heart disease, vascular disease, and osteoporosis. Along with B6 and B12, active folate helps break down homocysteine.*

Why Combine B12 and Folic Acid?

Folic acid supplementation can mask signs of B12 deficiency, so it is very important to take folic acid in combination with B12 to avoid B12 deficiency and the conditions such deficiency causes!*

Bevko's B12 Plus Active Folate

Bevko’s B12 Plus Active Folate lozenges contains 5,000 mcg. of methylcobalamin and 800 mcg. of Folate. Bevko chooses to use the methylcobalamin form of B12, which is preferred over the cyanocobalamin form (note that the prefix cyano refers to cyanide).*

Disclaimer:

*These statements above have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

References

1. Korem, M.; Almog, R.; and Galboiz, Y. Vitamin B12, demyelination, remyelination and repair in multiple sclerosis. Journal of the Neurological Sciences. 233(1-2):93-7, 2005 Jun 15
2. Wright, CB; Paik, MC; Brown, TR; Stabler, SP; Allen, RH; Sacco, RL; and. DeCarli, C. Total homocysteine is associated with white matter hyperintensity volume: the Northern Manhattan Study. Stroke. 36(6):1207-11, 2005 Jun.
3. van Asselt, DZ; Pasman,JW; van Lier ,HJ; Vingerhoets, DM; Poels, PJ; Kuin, Y; Blom, HJ; and Hoefnagels, WH. Cobalamin supplementation improves cognitive and cerebral function in older, cobalamin-deficient persons. Journals of Gerontology Series A-Biological Sciences & Medical Sciences. 56(12):M775-9, 2001 Dec.
4. den Heijer, M; Brouwer, IA; Bos, GM; Blom,HJ; van der Put, NM; Spaans, AP; Rosendaal, FR; Thomas, CM; Haak, HL; Wijermans, PW; and Gerrits, WB. Vitamin supplementation reduces blood homocysteine levels: a controlled trial in patients with venous thrombosis and healthy volunteers. [Randomized Controlled Trial] Arteriosclerosis, Thrombosis & Vascular Biology. 18(3):356-61, 1998 Mar.
   Rodrigo, R; Passalacqua, W; Araya, J; Orellana, M; and Rivera, G. Implications of Oxidative Stress and Homocysteine in the Pathophysiology of Essential Hypertension. Journal of Cardiovascular Pharmacology. 42(4):453-461, October 2003.
5. Wattanapenpaiboon, N. Cardiovascular risk in the Asia-Pacific region from a nutrition and metabolic point of view: vitamin deficiencies. Asia Pacific Journal of Clinical Nutrition. 10(2):103-107, June 2001
6. Clarke, R. and Armitage, J. Vitamin Supplements and Cardiovascular Risk: Review of the Randomized Trials of Homocysteine-Lowering Vitamin Supplements. Seminars in Thrombosis & Hemostasis. Hyperhomocysteinemia. 26(3):341-348, June 2000.
7. Hankey, GJ and Eikelboom, JW. Homocysteine and vascular disease. Lancet. 354(9176):407-413, July 31, 1999
8. Glueck, CJ, et al: Evidence that homocysteine is an independent risk factor for atherosclerosis in hyperlipidemic patients. Am J Cardiol 1995;75: 132-126.
9. Van Goor; et al: Cobalamin deficiency and mental impairment in elderly people. Age Aging 1995;24:536-542.
10. Abalan F, et al: Frequency of deficiencies of vitamin B12 and folic acid in patients admitted to a geriatric-psychiatry unit, Encephale 1984; 10:9-12.
11. Nilsson,K; Gustafson, L; and Hultberg, B. Plasma homocysteine is a sensitive marker for tissue deficiency of both cobalamines and folates in a psychogeriatric population. Dement Geriatr Cogn Disord 1999 November December; 10(6): 467-482.
12. Regland, B; Anderson, M; Abrahamson, L; Bagby, J; Dyrehag, LE; and Gottfries, CG. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scand J Rheumatol 1997;26(4): 301-307